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张东伟 副教授

  

 

  

  --姓名: 张东伟            职称:副研究员

  --学校: 北京中医药大学

  --电话.:  01186-6428-6915;

  --Email:  zhdw1006@163.com

  --地址:   北京市北三环东路11号北京中医药大学糖尿病研究中心

工作经历

     2012.6—至今     北京中医药大学基础医学院   副研究员

   2012.2—2012.6   国家食品药品监督管理局高级研修学院

   2010.6—2012.12    加拿大不列颠哥伦比亚大学  副研究员

   2006.10-- 2010. 5    加拿大不列颠哥伦比亚大学  博士后

   2004.7-- 2006.10     清华大学化学系    博士后

教育经历

    2001.9--2004.7  北京中医药大学,博士(生物化学)

   1998.9--2001.7  河南中医学院,硕士(药理学)

   1993.9--1997.7  河南中医学院,学士(药学)

研究兴趣

   (1) 代谢性疾病的发病机理.

    (2) 蛋白酶和疾病的关系.

    (3) 药物作用的生化机理和创新药物的研发.

科学研究  

  (1)2017年北京市自然基金面上项目:基于Wnt/β-Catenin研究女贞子对去卵巢骨质疏松大鼠的作用机理和物质基础(项目负责人)

  (2)2012年国家自然基金面上项目:基于中药选择性Cathepsin K活性的抑制剂对骨质疏松分子作用机理的研究。(项目负责人)

  (3)2012年国家自然基金面上项目:基于蛋白酪氨酸磷酸酯酶1B的调节作用的姜黄素抗糖尿病分子机制的研究。(申请书主要完成人和项目第二负责人)

  (4)2011年科技部重大新药研究项目:治疗糖尿病候选药物降糖消渴颗粒的研究。(主要参与人员)

  (5)2011年科技部国际合作项目:中医药干预糖尿病模型的关键技术和应用研究。(主要参与人员)

  (6)2008年科技部国际合作项目(加拿大与中国清华大学):从天然产物中筛选骨吸收特异性抑制剂的研究。加拿大方面主要参与人。

  (7)2008年国际合作项目(加拿大与中国北京中医药大学):组织蛋白酶与肺纤维化。加拿大方面主要参与人。

  (8)2004年国家自然科学基金项目--蛋白酪氨酸磷酸酯酶抑制剂的研制及抑制剂与酶的作用机理研究。

近几年主要发表文章(*责任作者) 

     (1)Ruyuan Zhu1+, Haixia Liu1+, Chenyue Liu, Lili Wang, Rufeng Ma, Beibei Chen, Lin Li, Jianzhao Niu, Min Fu, Dongwei Zhang*, and  Sihua Gao*.  Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety. Pharmacological Research. 2017, 122: 78-89.

    (2)Lili Wang+, Rufeng Ma+, Yubo Guo, Jing Sun, Haixia Liu, Chenyue Liu, Ruyuan Zhu, Jun Li, Liping Sun, Yushan Gao, Shujing Zhang, Jinfa Tang,    Guangjian Jiang, Dandan Zhao, Fangfang Mo, Yu Li, Jianzhao Niu, Shangang Zhao, Min Fu, Dieter Bromme, Sihua Gao* and Dongwei Zhang*. Fructus  ligustri lucidi exhibits antioxidant effects via regulating NOX4-ROS-NF-κB pathway in ovariectomized rats. Frontiers in Pharmacology. 2017, 8:266.

    (3)Xuejiao Sun, Yi Liu, Cheng Li, Xiting Wang, Ruyuan Zhu, Chenyue Liu, Haixia Liu, Lili Wang, Rufeng Ma, Min Fu, Dongwei Zhang*, and Yu Li*. Recent   Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis, BioMed Research International, 2017,2017: 2418671.

    (4)Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang,Yu Li, Jianzhao Niu, Min Fu, Sihua Gao*, Dongwei Zhang*.  Salvia miltiorrhiza: A potential red light to the development of cardiovascular diseases. Current Pharmaceutical Design. 2017, 23(7):1077-1097.

   (5)Liu C, Ma R, Wang L, Zhu R, Liu H, Guo Y, Zhao B, Zhao S, Tang J, Li Y, Niu J, Fu M, Zhang D*, Gao S*. Rehmanniae Radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology. Journal of Ethnopharmacology. 2017, 198:351-362.

  (6)Ma R+, Wang L+, Zhao B+, Liu C, Liu H, Zhu R, Chen B, Li L, Zhao D, Mo F, Li Y, Niu J, Jiang G, Fu M, Bromme D, Gao S*, Zhang D*. Diabetes  Perturbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A/IGF-1/β-Catenin in Rats. Celluar Physiology and Biochemistry.  2017;41(1):55-66.

  (7)Haixia Liu, Ruyuan Zhu, Chenyue Liu, Rufeng Ma, Lili Wang, Beibei Chen, Lin Li1, Jianzhao Niu, Dandan Zhao, Fangfang Mo, Min Fu, Dieter Bromme,  Dongwei Zhang*, and Sihua Gao*. Evaluation of Decalcification Techniques for Rat Femurs Using HE and Immunohistochemical Staining. BioMed Research International. 2017; 2017: 9050754.

  (8)Attané C, Peyot ML, Lussier R, Poursharifi P, Zhao S, Zhang D, Morin J, Pineda M, Wang S, Dumortier O, Ruderman NB, Mitchell GA, Simons B, Madiraju  SR, Joly E, Prentki M*. A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice.  Diabetologia. 2016, 59(12):2654-2663.

   (9)Attané C, Peyot ML, Lussier R, Zhang D, Joly E, Madiraju SR*, Prentki M*. Differential Insulin Secretion of High-Fat Diet-Fed C57BL/6NN and  C57BL/6NJ Mice: Implications of Mixed Genetic Background in Metabolic Studies. PLoS One. 2016, 11(7):e0159165.

   (10)Shangang Zhao, Yves Mugabo, Gwyn Thomas, Camille Attane, Jose Iglesias, Pegah Pourshaifi, Dongwei Zhang, Thuy Anne Nguyen, Raphael Prentki,  Marie-line Peyot, Erik Joly, Stephanie Tobin, Stephanie Fulton, J. Mark Brown, S.R. Murthy Madiraju*, Marc Prentki*. a/b-Hydrolase domain-6 deletion  induces adipose browning and prevents obesity and type-2 diabetes. Cell Reports, 2016, 14(12):2872-88.

   (11)Yves Mugabo, Shangang Zhao, Annegrit Seifried, Sari Gezzar, Anfal Al-Mass, Dongwei Zhang, Julien Lamontagne, Camille Attane, Pegah Poursharfi,   Jose Iglesias, Erik Joly, Marie-Line Peyot, Antje Gohla, S. R. Murthy Madiraju, Marc Prentki.  Identification of a mammalian glycerol-3-phosphate   phosphatase: Role in metabolic control and signaling in pancreatic β–cells and hepatocytes. Proceedings of the National Academy of Sciences.  2016,26;113(4):E430-9.

  (12)Rufeng Ma+, Ruyuan Zhu+, Lili Wang+, Yubo Guo, Chenyue Liu, Haixia Liu, Fengwei Liu, Hongjun Li, Yu Li, Min Fu, Dongwei Zhang*. Diabetic  osteoporosis: A review of its traditional Chinese medicinal use, clinical and preclinical research. Evid Based Complement Alternat Med. 2016; 2016:3218313.

  (13)Yubo Guo+, Lili Wang+, Rufeng Ma+, Qianqian Mu, Na Yu, Yi Zhang, Yuqing Tang, Yu Li, Guangjian Jiang, Dandan Zhao, Fangfang Mo, Sihua Gao*, Meijuan Yang, Feifei Kan, Qun Ma, Min Fu, Dongwei Zhang*. JiangTang XiaoKe granule attenuates cathepsin K expression and improves IGF-1 expression  in the bone of high fat diet induced KK-Ay dia betic mice. Life Sciences. 2016, 148: 24-30.

 (14)Lili Wang, Yu Li, Yubo Guo, Rufeng Ma, Min Fu, Jianzhao Niu, Sihua Gao, Dongwei Zhang*. Herba Epimedii: An ancient Chinese herbal medicine in the  prevention and treatment of osteoporosis. Current Pharmaceutical Design. 2016, 22(3):328-49.

 (15)Jiang GJ, Zhang T, An T, Zhao DD, Yang XY, Zhang DW, Zhang Y, Mu QQ, Yu N, Ma XS, Gao SH*. Differential Expression of Long Noncoding RNAs  between Sperm Samples from Diabetic and Non-Diabetic Mice. PLoS One. 2016, 11(4):e0154028.

 (16)Jiang G, Zhang G, An T, He Z, Kang L, Yang X, Gu Y, Zhang D, Wang Y*, Gao S*. Effect of Type I Diabetes on the Proteome of Mouse Oocytes. Cell    Physiol Biochem. 2016; 39(6):2320-2330.

(17)Qianqian Mu, Xin Fang, Xiaoke Li, Dandan Zhao, Fangfang Mo, Guangjian Jiang, Na Yu, Yi Zhang, Yubo Guo, Min Fu, Jun-Li Liu, Dongwei Zhang, Sihua  Gao*. Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications. 2015, 466 (3):530-535.

 (18)Fu XY, Zhang DW, Li YD, Zhao PW, Tang YQ, Niu JZ, Li Y. Curcumin Treatment Suppresses CCR7 Expression and the Differentiation and Migration of  Human Circulating Fibrocytes. Cell Physiol Biochem. 2015;35(2):489-98.

 (19)Fang X, Miao XL, Liu JL, Zhang DW, Wang M, Zhao DD, Mu QQ, Yu N, Mo FF, Yin HP, Gao SH. Berberine induces cell apoptosis through cytochrome C/apoptotic protease-activating factor 1/caspase-3 and apoptosis inducing factor pathway in mouse insulinoma cells. Chin J Integr Med. 2015 Jul 4.

 (20)Yubo Guo, Yu Li, Liming Xue, Richele P. Severino, Sihua Gao, Jianzhao Niu, Lu-Ping Qin, Dongwei Zhang*, Dieter Brömme*,  Salvia miltiorrhiza: An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs. J Ethnopharmacol. 2014, 155(3):1401-16

 (21)JunYu Ma, Guangli Zhang, Fang-Fang Mo, Dongwei Zhang, Sihua Gao, Qing-Yuan, Xiu Liu. Protein profiling analysis of the differences between diabetic  and normal mouse cumulus cells. Molecular Reproduction and Development , 2014, 81(12):1080-5.

 (22)Dandan Zhao, Na Yu, Xiaoke Li, Xin Fang, Qianqian Mu, Peijie Qin, Yue Ma, Fanfang Mo, Dongwei Zhang, Sihua Gao. Antidiabetic and antioxidative  effect of jiang tang xiao ke granule in high-fat diet and low-dose streptozotocin induced diabetic rats. Evid Based Complement Alternat Med. 2014, 2014:475192.

 (23)Dong-wei Zhang*, Min Fu, Si-Hua Gao, and Jun-Li Liu, Curcumin and Diabetes: A Systematic Review, Evidence-Based Complementary and Alternative Medicine, 2013, 2013: 636053,.

发布日期:2015年02月12日