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Diabetes Research Center


  Diabetes Research Center (DRC) is a domestic and international research platform combining of theoretical, clinical, experimental and new drug developing researches, which was established given the current situation that Chinese medicine plays a significant role in preventing and controlling diabetes, its complications and comorbidities, taking the advantages of relevant resources and facility conveniences in Beijing University of Chinese Medicine.


  Institutions: DRC includes three clinical laboratories, which are set up in the affiliated hospitals of BUCM, a drug researching lab, which is located in College of Traditional Chinese Pharmacy of BUCM, and the experimental research lab in YiFu researching building of BUCM, which is equiped with advanced laboratory apparatus, such as Thermal Texture Maps (TTM), fluorescent inverted microscope, clean bench, biological safety cabinet (BSC), electrophoresis equipment, and so on, to ensure the implement of both in vitro and in vivo studies, as well as researches in morphology and molecular biology level, etc.


  Staff: three categories of staffs, consisting official researchers, part-time employees and mobile personnel. Professor Si-hua Gao is the director of the research center, Guang-jian Jiang, Dong-wei Zhang, and Fang-fang Mo are the key technicians, who are in charge of the specific studying and managing affairs in research lab. Clinical experts of affiliated hospitals like Jin-xi Zhao and Yan-bing Gong work as the technical backbone in the clinical lab; professors such as Jian Ni and Kan-hai Xu from College of Traditional Chinese Pharmacy undertake researches in drug-developing lab. In addition, mobile technical personnel who are engaged in researching and new-drug-developing area and many graduate students are recruited each year.


  Features: combination of introduction and outraduction is the developing mode, linking by the projects. DRC has established international collaboration with research centers in Japan, the United States, and Canada, introduced advanced technology and methods and set up the technological platform of intervention in insulin resistance with TCM .


  (1) Two types of metabolic syndrome model rats, SHPSP-ZF rats, and SHR/NDmcr-cp rats were introduced from Mukogawa Women's University, Japan for studying the effect of Chinese medicine on insulin resistance.

  (2) The technology of abstracting and screening active ingredients from Chinese herbal drugs was introduced from Harvard University, America for research and development of novel Chinese drugs.

  (3) The method and techniques of constructing peritoneal fibrosis in mice models by adenovirus transfection were introduced from McMaster University, Canada, so as to perform researches on the acting mechanism of Chinese medicine in renal fibrosis of diabetic nephropathy.


  Ideas and achievement: Clinical study of treatment for type 2 diabetes based on liver, spleen and kidney syndrome differentiation whose principal professor is Si-hua Gao has won the national scientific and technological progress award in 2011.

  Innovations of clinical and basic researches include putting forward the conception that treatment for type 2 diabetes should base on liver, spleen and kidney syndrome differentiation, and developing novel treatment and drugs guiding by this treating principle. Results of syndrome investigation through statistical methods have also illustrated the objectivity of this idea. Many papers has been published relating to the studying results of this idea, and even been edited into diagnosis and treatment of diabetes and its complications by integrated Chinese and western medicine (second edition).


  Projects: current projects undertake by DRC include

  Grant from 973 program – Applied basic research on Zang-fu organ theory of lung and large intestine are exterior-interiorly related

  New Drug Development Program from ministry of science and technology – study of anti-diabetic effect of Jiangtang Xiaoke granule

  International cooperation project from the ministry of education – Research and application of key technology and models for intervening diabetes by traditional Chinese medicine


  National Natural Science Foundation of China –

  Anti-diabetic mechanism of curcumin based on its regulation function of protein tyrosine phosphatase 1 b (PTP1B)

  And Study of the molecular mechanism of the Chinese medicine selectively inhibiting to Cathepsin K activity on osteoporosis


  Projects funded by Beijing municipal board of education –

  Study of gasification theory and system of meteorological early warning for disease

  And Research on the prevention and treatment of metabolic syndrome with Chinese medicine